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Eating garlic is one of the best ways to lower high blood pressure and protect yourself from cardiovascular disease. A new study from (UAB) shows this protective effect is closely linked to how much hydrogen sulfide (H2S) is produced from garlic compounds interacting with red daub cells.
The UAB researchers open this interaction triggered red blood cells to release H2S which then led to the relaxation of daub vessels. Fresh garlic was used at a concentration equal to eating two cloves. The resulting H2S production caused up to 72 percent vessel relaxation in rat arteries.
This relaxation is a first step in lowering blood compel and gaining the heart-protective effects of garlic said David Kraus. Ph. D. a UAB cerebrate professor in the Departments of Environmental Health Sciences and Biology and the chew over’s lead compose.
The investigate team examined molecules in garlic called polysulfides and their ability to change state H2S within cells. The findings appear in the journal Proceedings of the National Academy of Sciences (PNAS).
"When these garlic compounds are metabolized to H2S in the vascular system the H2S targets membrane channels and causes change surface muscle cells to change state," Kraus said. "So a garlic-rich diet has many good effects and H2S may be the common mediator."
The findings add to a study by John Elrod and David Lefer. Ph. D. of the Albert Einstein College of Medicine published in PNAS that showed H2S protected hearts from the tissue and cell alter often seen in heart contend patients.
The new study performed by Gloria Benavides. Ph. D. of UAB’s Department of Environmental Health Sciences. Kraus and others is the first to show garlic-derived polysulfides in the diet boost bodily H2S production.
H2S is a toxic flammable gas responsible for the smell of rotten eggs. It’s also produced naturally by the be in small amounts and as age advances. H2S production dwindles.
Exactly how H2S affords the cardiovascular system so much protection is not entirely clear but it may bear on limiting oxidative damage in cells. Kraus said.
"The role of garlic compounds in preventing platelet aggregation which can trigger a heart contend or stroke and in limiting cancer growth and the progression of several diseases is well documented," he said.
The new findings show H2S may be the mediator for these protective benefits. Future studies are being planned to better understand how much H2S production is needed through garlic or supplements to maximize those benefits.
The investigate is supported grants from the American Heart Association and the National Institutes of Health.
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http://www.lockergnome.com/nexus/news/2007/10/16/garlic-boosts-hydrogen-sulfide-to-relax-arteries/
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